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Scientists identify new gene differences in severe COVID patients

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  • The scientists said their discoveries, could help prioritise the likely treatments that could work against the disease.
  • The information could even help predict which patients were likely to become severely ill.
  • The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.

Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study published on Monday that could help researchers develop treatments for very sick patients.

The results suggest that people with severe COVID have genes that predispose them to one of two problems: failure to limit the ability of the virus to make copies of itself, or excessive inflammation and blood clotting.

The scientists said their discoveries, published in the journal Nature, could help prioritise the likely treatments that could work against the disease.

Eventually, the information could even help predict which patients were likely to become severely ill.

“It is potentially possible in future that we will be able to make predictions about patients based on their genome at the point of presenting (for) critical care,” said Kenneth Baillie, consultant in critical care medicine at the University of Edinburgh and one of the study authors, told reporters.

The genetic analysis of nearly 56,000 samples from people in Britain showed differences in 23 genes in COVID-19 patients who became critically ill, when compared with the DNA of other groups included in the study, including 16 differences that had not been previously identified.

The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.

For example, the researchers found changes in key genes that regulate the level of factor VIII, a protein involved in forming blood clots.

“Blood clotting is one of the main reasons why patients with COVID develop a shortage of oxygen. So that’s potentially targetable to prevent those clots from forming,” Baillie said.

But “we can’t know if these medicines will work until we try them in people”.

One of the previously discovered genes, TYK2, is targeted by Eli Lilly’s arthritis drug baricitinib, now being studied as a treatment for COVID-19.

The drug was shown last week to cut the risk of death and hospitalisation in COVID-19 patients by 13% in a trial.

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Preliminary ruling on Sheikh Rashid’s exoneration plea on conspiracy to assassinate President Zardari

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On Thursday, the Islamabad District and Sessions Court reserved judgment on Sheikh Rashid’s (leader of the Awami Muslim League) appeal in the matter of alleged plot to assassinate President Asif Ali Zardari.

Earlier, Sheikh Rashid sought exoneration in the matter by lodging a plea.

On Thursday, the session was presided over by Civil Judge Yasir Mehmood.

The ex-minister of the federal government and his legal team made an appearance in court.

In court, lawyer Sardar Razaq contended that the FIR filed against Sheikh Rashid did not adhere to the law.

The veteran politician’s lawyer begged the court to clear his client’s name in the case that was filed with the Abpara Police Station.

The case’s ruling was postponed by the court.

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KP CM Ganadapur granted three weeks of travel bail by PHC

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The chief minister of KP, Ali Amin Gandapur, has been granted three weeks of transit bail in his plea with the Peshawar High Court (PHC).

The appeal for information regarding charges against Chief Minister Ali Amin Gandapur was considered by a two-judge panel from the PHC, which included Chief Justice Ishtiaq Ibrahim and Justice Sahibzada Asadullah.

The chief justice noted that the chief minister showed up for the court hearing, even though he was actually scheduled to be in Islamabad for an IMF meeting.

The applicant’s legal representative has asked for specifics of all pending charges against Chief Minister Gandapur, including those in Punjab.

According to the assistant attorney general, he told the ministry of the interior to adhere rigidly to court orders.

According to CJ Ibrahim, they have the option to request a response from the federal government and extend protection bail up to the Punjab region.

In every case, the additional attorney general ensured that court orders were implemented. He said that he had written to each district and requested details from the Punjab Police and the Inspector General.

The assistant attorney general has asked for an extension of three weeks to complete the report.

Gandapur could not attend the court daily due to his administrative duties and his position as chief minister and public office holder, according to Justice Asadullah.

After extending KP CM’s protective bail, the judge postponed the case hearing to December 17.

“Prepared to Protest”

Speaking to the media outside of PHC, KP CM Ali Amin Gandapur declared that he was prepared for the PTI protest meeting and that this time, the action plan will be stringent but undisclosed.

He emphasized that their peaceful protest was in accordance with their constitutionally protected right. According to him, his group was attacked, rubber bullets were shot, and routes were blocked so that protests couldn’t take place.

Importantly, on November 24th, Aleema Khan, who is the brother of PTI founder Imran Khan, said that her brother had called for a final protest.

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A response to an intra-party election case has been granted an extension by PTI.

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The matter involving PTI’s intra-party elections was heard by the Election Commission of Pakistan (ECP), and the party once again asked for more time to respond.

Barrister Gohar Ali Khan, chairman of the PTI, and petitioner Akbar S. Babar were both present before a two-member ECP court that heard the matter.

In response to PTI’s plea for additional time to respond, the Election Commission extended the deadline.

Additional case proceedings will not resume until December 4, per the commission’s adjournment.

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